ECHA has added four new chemical substances to the candidate list due to their toxicity to reproduction, endocrine disruption and it also effects the human health and the environment, giving rise to an equivalent level of concern to carcinogenic, mutagenic and reprotoxic (CMR), persistent, bioaccumulative and toxic (PBT) and very persistent and very bioaccumulative (vPvB) substances. The table below shows the details of the four-substance added. Substance name EC number CAS number Reason for inclusion Examples of use(s)
1 2-methoxyethyl acetate 203-772-9 110-49-6 Toxic for reproduction (Article 57 (c)) Not registered under REACH.
2 Tris(4-nonylphenyl, branched and linear) phosphite (TNPP) with ≥ 0.1% w/w of 4-nonylphenol, branched and linear (4-NP) Endocrine disrupting properties (Article 57(f) – environment) Primarily used as an antioxidant to stabilise polymers.
3 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts and its acyl halides (covering any of their individual isomers and combinations thereof) Equivalent level of concern having probable serious effects to the environment (Article 57(f) – environment) Processing aid in the production of fluorinated polymers.
Equivalent level of concern having probable serious effects to human health (Article 57(f) – human health)
4 4-tert-butylphenol 202-679-0 98-54-4 Endocrine disrupting properties (Article 57(f) – environment) Used in coating products, polymers, adhesives, sealants and for the synthesis of other substances.


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