The Environmental Protection Agency (EPA) needs to evaluate many PFAS for potential human and ecological effects. Most of the hundreds of PFAS currently in commerce have limited or no toxicity data, and if EPA attempts to research them one at a time, it will be impossible for EPA to expeditiously understand, let alone address, the risks of these substances may pose to human health and the environment. To address this data gap and fundamentally advance our understanding of these substances, EPA has developed this National PFAS Testing Strategy (Strategy) to deepen understanding of the impacts of PFAS, including potential hazards to human health and the environment. This Strategy will help EPA identify and select PFAS for which the Agency will require testing using Toxic Substances Control Act (TSCA) authorities. The Strategy develops categories of PFAS based on information about similarities in structure, physical-chemical properties, and existing test data on the toxicity of PFAS (both publicly available and submitted to EPA under TSCA). Consideration of the existing toxicity data before requiring further testing also ensures adherence to the TSCA goal of reducing animal testing. EPA will use the Strategy to identify important gaps in existing data and to select one or more candidate chemicals within identified categories for additional study. EPA expects to exercise its TSCA section 4 order authority to require PFAS manufacturers to conduct and fund the studies. EPA plans to issue the first round of test orders on selected PFAS by the end of 2021 with additional phases thereafter.

Below is the List of PFAS Candidates for Testing:  

CAS RN Terminal Category Candidate PFAS Name
422-05-9  (‘Fluorotelomer PFAA precursors’, ‘lt8’)  2:1 Fluorotelomer alcohol 
115-25-3  (‘Non-PFAA perfluoroalkyls’, ‘volatile’) Octafluorocyclobutane
355-42-0  (‘Non-PFAA perfluoroalkyls’, ‘volatile’)  Perfluorohexane
3330-14-1  (‘Others’, ‘gte8’) 2H-Perfluoro-5-methyl-3,6-dioxanonane
2062-98-8 (‘Others’, ‘lt8’) Perfluoro(2-methyl-3-oxahexanoyl) fluoride
355-80-6 (‘Others’, ‘lt8’) 1H,1H,5H-Perfluoropentanol
27619-88-1 (‘Others’, ‘lt8’) 3,3,4,4,5,5,6,6,6-Nonafluorohexane-1-sulphonyl chloride
376-90-9 (‘Others’, ‘lt8’) Hexafluoroamylene glycol
1682-78-6 (‘Others’, ‘volatile’) 2,3,3,3-Tetrafluoro-2-(perfluoroethoxy)propanoyl fluoride
1623-05-8 (‘Others’, ‘volatile’) Perfluoropropyl trifluorovinyl ether
42532-60-5 (‘Others’, ‘volatile’)  2,3,3,3-Tetrafluoro-2-(trifluoromethyl)propanenitrile
475678-78-5 (‘Others, cyclic’, ‘gte8’) 3-Methyl-3-[[(3,3,4,4,5,5,6,6,6-nonafluorohexyl)oxy]methyl]-oxetane
38565-52-5 (‘Others, cyclic’, ‘gte8’) 3-(Perfluorohexyl)-1,2-epoxypropane
382-28-5 (‘Others, cyclic’, ‘lt8’) Perfluoro(N-methylmorpholine)
428-59-1 (‘Others, cyclic’, ‘volatile’) Trifluoro(trifluoromethyl)oxirane
15290-77-4 (‘Others, cyclic’, ‘volatile’) 1H,1H,2H-Perfluorocyclopentane
307-35-7 (‘PFAA precursors’, ‘gte8’) Perfluorooctanesulfonyl fluoride
69116-72-9 (‘PFAA precursors’, ‘lt8’) Methyl perfluoro-3-[(perfluoro-3-oxopropan-2-yl)oxy]propanoate
16090-14-5 (‘PFAA precursors’, ‘lt8’) Perfluoro(4-methyl-3,6-dioxaoct-7-ene)sulfonyl fluoride
423-39-2 (‘PFAA precursors’, ‘volatile’) Nonafluoro-1-iodobutane
375-72-4 (‘PFAA precursors’, ‘volatile’) Perfluorobutanesulfonyl fluoride
76-13-1 (‘PFAS derivatives’, ‘volatile’) 1,1,2-Trichloro-1,2,2-trifluoroethane
34455-29-3 (‘unclassified’, ‘gte8’) 6:2 Fluorotelomer sulfonamide betaine

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