The California Proposition 65 list was updated with the inclusion of two new carcinogenic substances through the LC mechanism on April 21, 2023.

The Office of Environmental Health Hazard Assessment (OEHHA) is adding 1,1,1-trichloroethane (CAS Registry Number 71-55-6) and leucomalachite green (CAS Registry Number 129-73-7) to the list of substances known to the State of California to cause cancer.

These compounds are listed in accordance with the "Labor Code" listing mechanism. The obligation for warnings for considerable exposure to certain chemicals will go into force on April 21, 2024.

1,1,1-trichloroethane and leucomalachite green meet the conditions for Proposition 65 designation as known to the state to cause cancer.

Volume 130, "1,1,1-Trichloroethane and Four Other Industrial Chemicals" (IARC, 2022a) and Volume 129, "Gentian Violet, Leucogentian Violet, Malachite Green, Leucomalachite Green, and CI Direct Blue 218" (IARC, 2022b) of the "IARC Monographs on the Identification of Carcinogenic Hazards to Humans" (IARC, 2022a) Based on substantial evidence of carcinogenicity in animals, the IARC found that 1,1,1-trichloroethane is "probably carcinogenic to humans" (Group 2A) (IARC, 2022a). Based on substantial evidence of carcinogenicity in animals, the IARC found that leucomalachite green is "possibly carcinogenic to humans" (Group 2B) (IARC, 2022b).