The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list 1-bromo-3-chloropropane (CAS RN 109-70-6), 1-butyl glycidyl ether (CAS RN 2426-08-6), and glycidyl methacrylate (CAS RN 106-91-2) as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986.

IARC has published on its website that 1-bromo-3-chloropropane and 1 butyl glycidyl ether are “possibly carcinogenic to humans” based on sufficient evidence of carcinogenicity in animals and strong evidence in experimental systems that they each exhibit key characteristics of carcinogens (IARC, 2020).

IARC concluded that glycidyl methacrylate is “probably carcinogenic to humans” based on sufficient evidence of carcinogenicity in animals, strong evidence that the chemical belongs, based on mechanistic considerations, to a class of reactive glycidyl epoxides, and strong evidence in human primary cells that the chemical exhibits key characteristics of carcinogens (IARC, 2020).