Diisocyanates should not be used on their own or as a constituent in other substances or in mixtures for industrial and professional uses in concentrations above 0.1 % by weight after 24 August 2023. Placing on the market will be restricted earlier – as of 24 February 2022.

Diisocyanates are respiratory and skin sensitizers. They are mainly used to make polyurethane products, such as foams, sealants, and coatings. Restricting their use is estimated to prevent over 3 000 new cases of occupational asthma per year in the EU. Read more about the conditions of the restriction in the Commission Regulation.

Reference: https://echa.europa.eu/substances-restricted-under-reach